Not wanting to feel the pain of losing his loved ones over and over again, Nicolas, an immortal man, keeps himself from falling in love. As he goes through life alone, he meets Sophia, the woman who changes his life forever.
In a stunning turn of events, Lorenzo, a poverty-stricken farmer, becomes immortal. Fast forward to 1988, his son's demise prompts him to change his identity.
Years after moving to Manila, Sophia finally decides to pursue her life-long dream of working on a cruise ship. Meanwhile, Lorenzo decides that it is time to put his identity as Nicolas Barrientos to rest.
As Sophia arrives in Amsterdam to a warm welcome from her best friend, Glenda, she unknowingly crosses paths with Nicolas. Elsewhere, Marlon receives a new lead on Lorenzo.
Unable to contain her curiosity, Sophia searches the ship for the mysterious passenger. Nicolas donates blood in hopes that it will help develop a cure for cancer.
Nicolas accompanies Sophia back to the cruise ship after coming across her on Bruges. Marlon orders his henchmen to abduct Helen.
Sophia finds herself in an awkward situation with Nicolas and a near-death incident brings them together. Marlon makes an effort to get closer to Helen.
Nicolas and Sophia grow closer as they spend more time together. The man becomes even more desperate to find a cure for his immortality, while Marlon continues to stalk Helen.
Sophia braves the storm to save Nicolas and their relationship blossoms. Olivia arrives in Cebu to spy on Marlon, while Helen becomes aware of George's deception.
Nicolas takes Sophia on a tour around Hamburg and introduces her to new experiences. Meanwhile, Marlon is severely disappointed after losing track of Helen.
Nicolas and Sophia’s budding romance starts to blossom as they visit Prague's tourist spots, unaware of the tragedy that awaits them. Philip arrives in Hamburg and boards a ship to surprise Sophia.
Sophia finds herself on pins and needles after failing to find Nicolas in the spot where he was stabbed. Meanwhile, Helen becomes determined to unmask Marlon.
Nicolas tasks Bing to persuade Sophia to abandon her desperate search for him. Back in the Philippines, Geoffrey comes up with a way to pay off his family's debts.
After revealing his past, Nicolas prepares a sweet surprise for Sophia before confessing his love for her. Helen discovers vital information about the man searching for Nicolas.
Sophia runs into Nicolas in Norway and learns that he has returned to the cruise. Philip, on the other hand, extracts an important promise from Sophia.
Sophia feels shy toward Nicolas after she admitted her feelings for him. Despite getting turned down, Philip sets another plan to win Sophia's heart but the repercussions of his actions put the woman's job and life in jeopardy.
Sophia returns to the Philippines after losing her job, and gets emotional upon recalling her memories with Nicolas in Prague. Nicolas asks Bing to get the contact information of Sophia despite his initial decision not to go after her anymore.
Sophia starts looking for a new job, but her bad record immediately turns off potential employers. Nicolas continues his search for Sophia, and informs Bing and Helen that he will be more active in finding a cure for his immortality.
Nicolas becomes more determined to find a cure for his immortality as he is eager to start a relationship with Sophia. Sophia ends up working as a server at an art exhibit where she bumps into an unexpected guest.
Nicolas gives Sophia an unwelcome gift. Annoyed by his presumptuousness, Sophia asks Nicolas to keep his distance for a while. Undeterred, Nicolas continues to use his wealth and connections to secretly aid Sophia. One of his attempts, however, leads to serious consequences.
During a photography workshop, Sophia is tasked to teach Nicolas. The two become more drawn to each other as she assists him with his shot compositions. However, their fun is cut short when the venue of the workshop catches fire, prompting Sophia to be plagued by her traumatic experience.
Sophia ends her relationship with Nicolas just as when he admits his feelings for her. While Nicolas resolves to find a cure for his immortality, Sophia remains bothered at the thought of him.
Sophia receives a call that Faye is missing. With Nicholas’ help, Sophia looks for her missing grandmother.
Nicolas tries an untested formula to cure his immortality. Meanwhile, the Madrids learn that Faye has Alzheimer’s disease.
Henry and Sally share their heartwarming love story to Sophia and Nicolas. Meanwhile, Philip accepts the task of finding the elusive Lorenzo.
Nicolas asks Sophia to give him another chance to prove himself. Despite his hectic schedule, Philip continues to try to find time for Sophia.
Sophia realizes her true feelings for Nicolas after saving him from drowning. Meanwhile, Bing visits the man who witnessed Nicolas’ revival.
Nicolas grants Sophia's birthday wish, and resolves to pursue a relationship despite its consequences. Meanwhile, Philip puts an effort to make Sophia feel special on her birthday.
Nicolas slowly reveals his past to Sophia. Helen discovers vital information about the man searching for Nicolas.
Excited to introduce Nicolas to her family, Sophia eagerly waits for him to arrive at her birthday celebration. However, Nicolas, Helen, and Bing meet an unexpected tragedy on their way to Sophia's house. Helen comes across Marlon and ends up in a compromising situation in her attempt to keep him from seeing Lorenzo.
Nicolas makes it up to Sophia after failing to show up on her birthday party. Nicolas then comforts Sophia as she blames herself for Philip's suffering. Later, Nicolas finds out the temporary effect of the cure he was working on. Meanwhile, Bing and Helen do a background check on Marlon and discover his connection with Sophia. Elsewhere, Philip is devastated about Sophia's revelation. After Marlon lashed out at him with insults, Philip answers by showing him the accomplishment of his task.
Helen decides to talk to Sophia, thinking that her relationship with Nicolas will keep putting his life at risk. However, before she could meet Sophia, Helen gets herself into danger. Despite his suspicion that he is the real target of Helen's assailants, Nicolas risks his life to save his foster daughter. Meanwhile, Sophia and the Madrids become worried when Faye goes missing again.
Nicolas puts his life on the line to save Helen and Faye. In a struggle that ensued between him and Marlon's men, Nicolas finds himself heavily wounded. This eventful encounter paves the way for Faye to uncover Nicolas' secret. She tries to tell her family about what she witnessed, but they refuse to believe her story. Later, Nicolas begins to grasp the consequences of having a relationship with Sophia.
Meanwhile, Sophia notices that Nicolas is becoming distant toward her. Nicolas, on the other hand, realizes that his reckless decisions are putting his loved ones in peril. He then comes up with a drastic decision involving Sophia.
Following their sudden breakup, Sophia fights for her love for Nicolas. Nicolas arrives at the place where he plans to fake his death, while the Borjas draw closer to finding the immortal man.
Sophia finally crosses paths with Nicolas, but the latter drives her away and decides to continue with his plans. Michael and his henchmen arrive in Isla Bughaw and try to capture the immortal man.
Nicolas finally turns his back on his budding relationship with Sophia and decides to leave behind his present life to keep Sophia safe from his enemies.
Lorenzo starts a new life in Poland with Bing, while Sophia tries to move on from the untimely death of her lover. Meanwhile, Marlon finds a way to locate Helen.
Lorenzo is forced to return to the Philippines as he deals with another devastating loss in his life. Meanwhile, Sophia gets back on her feet after the death of Nicolas.
Nicolas embraces a new identity in Poland and continues his quest to find cure for various diseases using his condition. Sophia faces a new problem just when things are going well for her.
While in Poland, Laurence makes up his mind to finally leave the past behind and finds solace in his new life as a doctor. Sophia embraces the challenges of raising her child as a single parent.
Because of impending danger, Nicolas and Bing escape to Prague where they unexpectedly encounter Sophia and her son.
Marlon is forced make several grim decision regarding Borja Pharmaceuticals. Laurence returns to the Philippines to find out the truth about Adrien.
Sophia's chance encounter with Laurence at Adrien's school casts doubts on her plan to get married to Philip. Laurence receives confirmation that Adrien is his son.
Matthew and Lawrence agree to meet with Eddie to discuss the latter's discoveries regarding Borja Pharmaceutical. Sophia finds proof that Nicolas and Lawrence are somehow connected.
A shocking discovery puts Nicolas' relationship with Sophia and Adrien in limbo. Overcome with doubt, Sophia makes a shocking decision regarding her wedding plans.
Philip finds it hard to accept that things are already over between him and Sophia. Meanwhile, Marlon and Michael find a possible investor for their company.
Sophia's rejection starts to take its toll on Philip. To make matters worse, he soon discovers that Lawrence is Adrien's biological father. Determined to keep his son out of Marlon's reach, Lawrence resolves to reveal to Sophia the truth.
Lawrence does everything in his power to convince Sophia that he is immortal. Marlon tries to convince Lawrence to invest in his quest to invent a miracle drug.
Philip refuses to give up on Sophia despite her constant rejection. He instead decides to investigate Lawrence with the goal of removing him from Sophia's life.
Geoffrey discovers Marlon's unrelenting desire to hunt down the immortal man. Lawrence agrees to a meeting with Marlon, unaware that the latter has already found out the truth.
Lawrence manages to escape from Marlon with Matthew's help. Determined to hunt down the immortal man, Marlon enlists Olivia's aid in locating Lawrence. Soon, the safety of one of Lawrence's loved ones is put at risk.
After Marlon lashed out at her for her betrayal, Olivia takes Philip away and seeks help from the Madrids. Marlon vows to make Lorenzo pay for Michael's death. Meanwhile, Lawrence resolves to find a cure for his and Adrien’s immortality.
Determined to take Sophia and Adrien away from Lawrence, Philip unwittingly leads Marlon to their location. Marlon wastes no time and kidnaps Sophia and Adrien.
Lawrence gives Marlon the immortality formula in exchange for Sophia and Adrien's freedom. However, Marlon reneges on his end of the deal. He decides to keep the entire family captive and prepares a torturous setup to exact his revenge on Lorenzo.
Sophia rushes Philip to the hospital after he took a bullet for her. Soon, Lawrence focuses on his promise to live a normal life with Sophia and Adrien. Aware that he must give up his immortality to fulfill that promise, Lawrence comes to a decision.
