As a U.S. Deputy Marshal, based on Miami, Florida's Gold Coast, Karen must deal with the underbelly of South Beach nightlife and Palm Beach high life while tracking down fugitives. She also struggles to win the respect of her fellow officers. Karen occasionally gets advice from her father, a retired Miami police officer turned private investigator, who is Karen’s confidant, counselor, and confessor.
An effort to apprehend a fugitive goes wrong, almost putting a bullet through Karen's heart and leaving one man dead. But she's having trouble remembering what happened so she can write a report to satisfy Internal Affairs. Meanwhile, Karen's in for heartache of a different kind when she learns that the good-natured charter fisherman she's dating may actually be a bank robber, at least according to the FBI agents on his trail.
When Florida's two stupidest cons, the Salchek brothers, escape from prison and steal a baseball worth millions from infamous mob boss Charlie Lucre, Karen turns to their mother, a hapless waitress living in a trailer park, for clues on how to find them before Lucre's hitmen do.
When a suave con artist who bilks women out of their fortunes manages to slip away from Karen the minute he's off the plane, she's humiliated but determined to bring him in, despite the fact the FBI has ordered her off the case. Meanwhile, a former mob accountant suddenly returns from hiding in the witness protection program, putting his — and Karen's — life in jeopardy; and Marshall is unhappy to find that Karen's old boyfriend, a married FBI agent, is back on the scene.
Karen reluctantly teams with Konner, a legendary marshal new to the Miami office, to hunt down three parolees who have gone on a crime spree, unaware that the cons — all former gang members — have a link to Konner's past and that he intends to mete out his own deadly brand of justice.
Karen must protect a counterfeiter who claims they went to high school together and appears to be the target of a mob boss. Meanwhile, Marshall's past comes to haunt him when an ex-con decides to settle a very old score.
It looks like Karen's budding romance with a sexy Miami Marlins pitcher will never get to third base, as her assignment — to bring in a prison escapee determined to be reunited with his stripper girlfriend — wreaks havoc with her personal life.
Karen is assigned to track down a fugitive accountant on the lam for murder and the theft of hundreds of thousands of dollars from his high-end fashion boss. Meanwhile, Marshall meets an attractive woman who wants him to investigate her husband's infidelity.
While visiting the bank, Marshall and Karen are taken hostage. Karen and Marshall try to save the situation from the inside, while Karen's boss, Amos Andrews, tries to hold back the FBI. The FBI agent on the scene, Gil Bellows, is a little to eager to storm the bank, which might jeopardize the lives of the hostages.
A young girl witnesses the murder of her guardian (a snitch) by a drug dealer, and must be protected by Karen.
Karen goes undercover as an escort, and investigates designer drugs.
