Four old friends from high school find themselves at that stage where they realize that their lives didn't turn out exactly the way they'd planned. Over the course of one crazy evening, a series of calamities reunites this hapless brood at Los Angeles Westside Hospital, where they all find themselves under the care of a reluctant Dr. Joanna.
The opening episode of this new series explores the concept that who you were in high school is not what you will become. Harry, Jason, Sherman and Kelly discovered this fact on a day when they each had a personal emergency. This series of emergencies reunites the group and they find that, at the end of the day, that they've got each other in case of emergency.
Kelly's cop boyfriend catches Harry helping her move her things out of his place and he isn't happy about it. Jason is still trying to have something going on with Dr. Joanna while Sherman's staff refuses to help him to restore his professional reputation.
Sherman and Harry sneak into an ashram to extract Sherman's ex-wife. Kelly confesses to Harry what really happened to her husband, while Jason tries to convince Dr. Joanna's grandmother to accept medical treatment to save her life.
Harry quits his job because his boss chastises him, and Sherman tries to avoid hostile fellow shoppers at a supermarket while Jason dodges a process server.
While Harry begs Kelly not to tell Sherman and Jason that she's a hooker, Sherman discovers that Jason's investment company has lost all of his money, and Dr. Joanna rejects Jason's advances.
While Jason is jail bound and considers ratting out his uncle Henry to get a better deal, Jason's mother flirts with Harry. In the meantime, hoping to get him over his wife, Kelly takes Sherman to a strip club.
Jason finds out that his mom is sleeping with Harry. Sherman is having a hard time trying to stay on his diet. And Dylan gets a crush on Kelly.
While Sherman convinces Kelly to help him kidnap his wife, Harry reveals to Jason that he has sex with his mother and Jason tries to prove that Joanna kissed him.
After the surprise visit of Kelly to her strict parents, she decides to create a new life for herself and to start from scratch. She decide that the best way of doing it is by getting married, but things are getting complicated when she decides to choose Jason and not Harry and her parents demand that she have a traditional Korean wedding.
When Harry's son, Dylan, is repeatedly harassed by a school bully, Kelly decides to hire two goons from the massage parlor to protect him. Meanwhile, Jason finally gets Dr. Joanna to go out with him but, while they were going out, he finds himself mortified as all his possessions get repossessed right in front of her.
Harry and Sherman decides to go to a spa to escape women, but when they arrive Sherman begins the vacation by looking for women. Meanwhile, joanna is having problems with her neck. Each time Jason's name is mentioned, she gets a pain in her neck. she then decide to go for a massage but Kelly will be the masseuse.
Harry tries to get his ex-wife and her boyfriend to marry so he can stop paying the alimony and finally use his money to get back on track but he then learn that his son prefer his ex-wife new boyfriend more than him. During the meantime, Jason learns that his lawyer his Joanna's fiancé, while Sherman goes to rehab to help his public image.
While Harry and Maureen try to get back together, Joanna learns about her hidden attachment to Jason. Meanwhile, Shermans book goes #1 in Japan.
