A month after the events of 30 Days of Night (2007), prison nurse Sara Maguire is attacked by a vampire during a prisoner transfer and begins to turn, while her ex-cop brother Nick hunts for her, encountering escaped vampire hunter George Fowler along the way.
Nick's sister, Sara, is caught in the crossfire when vampires descend on Orleans County Penitentiary in an effort to assassinate George. Nick ignores the wishes of his former partner, Gina, and sets off to find Sara.
Nick & George's paths convene in the home of a local drug dealer. Nick wants answers, but George has other concerns at the moment. Those concerns are realized when he learns the vampire assassin has been following him across town.
Nick learns the truth about what's happening to his sister, while on the other side of town, Sara is making the horrifying discovery all for herself.
Another terrifying encounter forces Nick to start believing there may be more to his sister's disappearance than he could have ever possibly imagined.
As they wait for Sara's return, Nick and George are unaware of the danger lurking inside the house.
Nick and George face the vampire head on in this final showdown, only to realize it may be too late for Sara.
