The beginning is nigh.
A preacher sets out on a mission to make the almighty himself confess his sin of abandoning the world. With his best friend Cassidy, an alcoholic Irish vampire, his love Tulip, a red blooded gun towing Texan, and the power of genesis, an unholy child born from an angel and a devil, Jesse gives up everything to set the world straight with its creator.
Jesse is rocked by visions of an apocalyptic future as he and Tulip prepare for an all-out assault on Masada, where Cassidy – trapped to a torturous fate – struggles to hang on. But Starr and his Grail operatives are ready for them…
God maneuvers the chess pieces of His apocalypse closer to the endgame as Jesse takes off in search of a mysterious rock formation that may be the final leg of his journey. Meanwhile, Tulip devises one last-ditch effort to try and save Cassidy from his endless torture.
Tulip gets in too deep in Masada; Cassidy reflects on a lost life; the Saint closes in on Jesse.
Tulip forges an unexpected alliance to save Cassidy; Jesse finds himself stranded.
Tulip reunites with Cassidy and Eugene finds Jesse; the Grail's agenda threatens to unwind.
Tulip and Cass track Jesse and the Saint of Killers, while Starr searches for the missing messiah.
Tulip and Cass tear after God; an old friend presents Jesse with an unique opportunity.
Tulip and Cass struggle to keep Humperdoo hidden from the Grail, while Jesse remains MIA.
Jesse, Tulip and Cassidy mount one final assault on Masada as the Apocalypse Revue begins.
The curtain falls on the Apocalypse Revue as the fate of the world is decided, and the long journey of a preacher and his friends comes to an end.
